Another Genetic Cause Of Alzheimer’s Disease. Part 3 of 3

Another Genetic Cause Of Alzheimer’s Disease – Part 3 of 3

However, the current investigation into PS1 behavior side-steps this potential scenario – without questioning its validity – by focusing on the possibility that abnormal PS1 function may cause cell extirpation unconnected to beta amyloid buildup. PS1 mutations and other factors could, therefore, promote Alzheimer’s in entirely different ways, the team said.

So “There is an urgent need now to investigate Alzheimer’s disease as caused by multiple factors and approach the treatment from that perspective,” said Nixon, who added that the current finding opens up a new target for Alzheimer’s interventions down the road. Focusing on how to renew brain cells’ normal recycling system is a promising therapeutic approach since its disruption appears to promote Alzheimer’s helpful resources. Nixon and his colleagues report their findings in the June 10th online question of the journal Cell.

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Another Genetic Cause Of Alzheimer’s Disease. Part 2 of 3

Another Genetic Cause Of Alzheimer’s Disease – Part 2 of 3

And “Presently, no effective treatment exists to either slow or prevent the progression of Alzheimer’s disease,” added Nixon, also director of the Center for Dementia Research at the Nathan S Kline Institute for Psychiatric Research in New York City. “This detection has the potential of identifying such a treatment”.


Mutations of the PS1 gene have previously been thought to spread production of the toxic beta amyloid protein that appears to collect in the brains of Alzheimer’s patients. In turn, scientists have theorized that by preventing amyloid deposits from accumulating, they might be able to slow or curb Alzheimer’s progression.

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Another Genetic Cause Of Alzheimer’s Disease. Part 1 of 3

Another Genetic Cause Of Alzheimer’s Disease – Part 1 of 3

Another Genetic Cause Of Alzheimer’s Disease. Researchers have discovered that the change of a gene associated with early onset Alzheimer’s may block a key recycling process vital for brain cell survival – a finding that points the way to possible treatment for the disease. When it’s working properly, this gene – called presenilin 1 (PS1) – performs a momentous house-cleaning service by helping brain cells digest unwanted, damaged and potentially toxic proteins.

But in its mutated form, the gene fails to help cells recycle these unrealized toxins, suggesting an explanation for the damage to the brain characteristic of Alzheimer’s disease. “We believe we have identified the principal mechanism by which mutations of PS1 cause the most common genetic model of Alzheimer’s disease,” study co-author Dr Ralph A Nixon, professor in the departments of psychiatry and cell biology as well as director of NYU’s Center of Excellence on Brain Aging and the Silberstein Alzheimer’s Institute, said in a university intelligence release.

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Music And Heartbeat Disorder. Part 2 of 2

Music And Heartbeat Disorder – Part 2 of 2

This is especially apparent in the world of arts and music, which reflects so much of people’s innermost experiences”. Cardiac arrhythmia causes the spirit to beat too fast, too slow, or with an irregular rhythm. Sudden, unexpected beat and key changes in some of Beethoven’s music appear to match this variation in heart rhythm, the researchers said. The weigh authors also said that Beethoven’s hearing loss might have heightened his other senses and made him even more aware of his heartbeat.


The essay was published in the journal Perspectives in Biology and Medicine. There is no way to distinguish for certain whether Beethoven, who died in 1827, had cardiac arrhythmia. But the compositions analyzed by the researchers “may be ‘musical electrocardiograms,’ the readout of modern heart rhythm testing equipment,” Dr Zachary Goldberger, a cardiologist at the University of Washington School of Medicine and cause author of the essay, said in the news release recommended site. “While these musical arrhythmias may simply manifest Beethoven’s genius, there is a odds that in certain pieces his beating heart could literally be at the heart of some of the greatest masterpieces of all time”.

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Music And Heartbeat Disorder. Part 1 of 2

Music And Heartbeat Disorder – Part 1 of 2

Music And Heartbeat Disorder. A heartbeat malady may have influenced parts of composer Ludwig van Beethoven’s greatest works, researchers say. “His music may have been both figuratively and physically heartfelt,” have a go at co-author Dr Joel Howell, a professor of internal medicine at the University of Michigan Medical School, said in a university news release. The unconcerned composer has been linked with numerous health woes, and historians have speculated that the composer may have had an arrhythmia – an irregular heartbeat.

Now, a team that included a musicologist, cardiologist and medical historian suggest that the rhythms of firm sections of Beethoven’s most renowned pieces may reflect the irregular rhythms of his heart. “When your heart beats irregularly from heart disease, it does so in some predictable patterns. We think we hark some of those same patterns in his music. The synergy between our minds and our bodies shapes how we experience the world.

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Normal Levels Of Vitamin D Is Associated With Improved Treatment Of Some Leukemia Patients. Part 3 of 3

Normal Levels Of Vitamin D Is Associated With Improved Treatment Of Some Leukemia Patients – Part 3 of 3

Similar findings were seen in a different group of CLL patients who were followed for 10 years, according to the researchers. “This tells us that vitamin D insufficiency may be the principal potentially modifiable risk factor associated with prognosis in newly diagnosed CLL”. The researchers are planning another study to see if reversing low vitamin D levels in patients will progress their prognosis. The study appears online in the journal Blood as an example.

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Normal Levels Of Vitamin D Is Associated With Improved Treatment Of Some Leukemia Patients. Part 2 of 3

Normal Levels Of Vitamin D Is Associated With Improved Treatment Of Some Leukemia Patients – Part 2 of 3

And “This watch-and-wait make is difficult for patients because they feel there is nothing they can do to help themselves,” Shanafelt said in a Mayo news release. “It appears vitamin D levels may be a modifiable chance factor for leukemia progression. It is simple for patients to have their vitamin D levels checked by their physicians with a blood test. And if they are deficient, vitamin D supplements are a great extent available and have minimal side effects”.


This study of 390 CLL patients found that 30 percent of them had insufficient vitamin D levels (less than 25 nanograms per milliliter) at the organize of cancer diagnosis. After a median follow-up of three years, patients with insufficient vitamin D levels were 66 percent more likely to have disease progression and to require chemotherapy. They also had a twofold increased hazard of death, compared to those with adequate vitamin D levels.

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